Ginkgo Process Design & Scale Up Services

Overview

Scale up and deploy your optimized strains at commercial scale

Utilize Ginkgo’s best-in-class scale up, processing, and production services at bench, pilot, and commercial scales. Ginkgo’s capabilities enable and improve the scaled production of your product whether a cell or gene therapy, agricultural product, food protein, industrial commodity, or anything in between.

Have a question or ready to start a project?

End-to-End Capabilities.
No Matter the Scale.

From proof of concept in well plates, shake flasks and small bioreactor systems to modeling, analytical and process development, characterization, and commercial launch, Ginkgo’s services can help you move from R&D to scaled production.

Leverage Ginkgo’s internal labs and capabilities including quality control, upstream production, downstream purification, pilot plant facilities, technical transfer to a partnered Ginkgo manufacturing site or a CDMO preferred by the customer. Ginkgo’s team of experts will provide your project with process modeling, development, and optimization, analytical support including method development and validation as well as titer or purity determination, and tech transfer back to your team or to your preferred manufacturing partner.

How can we help you?

Microbial Fermentation Scale Up

Closeup shot of a row of automated small scale fermentation bioreactors

Microbial Fermentation Scale Up

  • Access our fermentation capacity, ranging from Ginkgo’s fleet of ~300 Sartorius Ambr® 250 bioreactors to our vessels spanning 1, 5, 10, 30, 300, and 3,000 L and all the way up to the 50,000 L scale with our manufacturing partners 

  • Rapidly evaluate strain candidates using our Ambr® 250 bioreactors to automate design of experiments at lab scale to quickly develop fermentation processes with a proven record of transferring to commercial scale

  • Leverage our process optimization expertise in a range of industrial microbes—including Escherichia coli, Bacillus subtilis, Pichia pastoris, Saccharomyces cerevisiae, Aspergillus niger, Corynebacterium glutamicum, and Yarrowia lipolytica—and many more model and nonmodel host organisms

Downstream Processing

Vials of purified samples

Downstream Processing

  • Utilize Ginkgo’s thermal, physical, and chemical separation capabilities to purify a sample for further analysis, testing, or proof of concept

  • Utilize our thermal separation capabilities including evaporation, distillation, and drying techniques

  • Use our physical separation capabilities including centrifugation and filtration techniques

  • Apply our variety of chemical separation capabilities including extraction, ion exchange, crystallization, chromatography, absorption, and adsorption techniques

Quality Control

A scientist inspecting a 96 well plate

Quality Control

  • Receive accurate and reproducible results as an outcome of working with Ginkgo and our QC team

  • Receive analytical quality support and project scoping at the start and throughout your project from our team of QC expertsLeverage our fermentation and downstream analytical titer or purity determination capabilities to accurately assess your strain’s performance

  • Enjoy quick project starts thanks to Ginkgo’s incoming analytical technology transfer capabilities and ensure smooth tech transfers back to your team or to your manufacturing partner of choice 

  • Utilize our analytical support services to assess the capabilities of other service providers such as contract development and manufacturing organizations (CDMOs)

Pilot Plant Scale Production

Pilot scale fermentation tank bioreactors

Pilot Plant Scale Production

  • Access the pilot scale you need by utilizing Ginkgo’s biologics pilot plant with microbial fermentation capabilities at 20, 300, and 3,000 L scales

  • Process your sample using our centrifugation, tangential flow filtration, spray drying, and other purification techniques

Project Engineering

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Project Engineering

  • Receive cost modeling and feasibility assessments from our team to inform your decision-making

  • Enjoy the benefits of Ginkgo’s project engineers who handle all aspects of contracts, procurement, scheduling, testing material, tech transfer to CDMOs and more

Speak with Us

Start a project today.

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Markets We Serve

Featured Projects & News

Ginkgo is your end-to-end synthetic biology R&D partner. Browse a selection of our partner projects and case studies to explore how biology is being used across industries.

Speak to our team today to access more.

Agriculture

Crop protection and nutrition, animal health and wellness, carbon solutions: we’re here to help. Explore our projects and learn more about how we help our partners in the agricultural sector.

Agriculture

Strain Improvement for Sustainable Agriculture with Bayer

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Two gloved hands holding the top and bottom of a petrid dish, one side filled with agar with hundreds of small colonies growing

Expanding Our Platform Capabilities in Agricultural Biologicals and Launching Flagship Partnership with Bayer

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Optimizing Enzyme Expression and Performance with Zymtronix

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Optimizing the Brightness of Glowing Plants with Light Bio

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Biopharmaceutical

Use our synthetic biology platform to discover, optimize, and scale up a wide range of therapeutic modalities. Explore our projects and learn more about how we help our partners in the biopharmaceutical sector.

Biopharmaceutical

Optimizing Crucial Drug Manufacturing of APIs with Merck

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Colorful yeast in plate

Unlocking the Potential of Expression Systems for Medicines with Novo Nordisk

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A 3D rendering of a protein

Improving the Specificity and Activity of a Biocatalyst

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Enzyme Discovery Powered by Large Metagenomic Libraries

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High Throughput Screening for Designing Novel CAR-T Cell Therapies

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Manufacturing Breakthrough for mRNA Raw Materials with Aldevron

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Advancing Treatments for Orphan and Rare Diseases with Selecta Biosciences

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Developing Next-Generation Gene Therapy Capsids with Selecta Biosciences

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Improving the Manufacture of Biosynthetic Heparin with Optimvia

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Investigational Synthetic Biotic Medicine for Homocystinuria with Synlogic

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Optimizing Enzyme Expression and Performance with Zymtronix

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Developing Circular RNA-based Therapeutics with Esperovax

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Engineering Bacteria for Cancer Patient Treatment with Prokarium

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New Platform Ventures: Launching Verb Biotics, Ayana Bio

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Accelerating Production of Essential Medicines with Antheia

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Developing High-Efficacy Adjuvants for Vaccines with SaponiQx

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A very fine illustration in green of an X-rayed T. rex with a bundle of E. coli in an inset circle and the word Sue written in cursive overlayed on top of everything

Developing Synthetic Biotics for Gout with Synlogic

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Digital collage of live bacterial biotherapeutics

Discovering Novel Live Biotherapeutics with Microba

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Engineering Living Biotherapeutics for Gastrointestinal Health with Tantu

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Needle in a Haystack: Looking for Compounds to Treat COVID-19

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Supporting COVID-19 mRNA Vaccine Development with Moderna

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Teaming Up to Improve Antibody Therapeutics for COVID-19

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A New Modality of Medicine: Nucleic Acid Vaccines

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Governments

Secure the things you care about the most — your people, your environment, your home. Explore our projects and learn more about how we help our partners in the public sector.

Governments

Building a Global Bioradar System with Concentric by Ginkgo

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Manufacturing Breakthrough for mRNA Raw Materials with Aldevron

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Tracking Pathogen Variants with Rwanda Biomedical Centre

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Supporting COVID-19 mRNA Vaccine Development with Moderna

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Expanding Ginkgo’s Platform for Biosecurity and Pandemic Responsiveness

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Accelerating Industrial Adoption of High-Performance Biomaterials with Cambium

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Developing Water Quality Biosensors with FREDSense

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Concentric by Ginkgo: COVID-19 testing at scale

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Industrials

Chemicals, materials, fuels, waste, mining, water treatment: biology is revolutionizing industrial processes. Explore our projects and learn more about how we help our partners in the industrial sectors.

Industrials

Aliquots

Optimizing Production of Biobased Speciality Chemicals with Lygos

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Accelerating Industrial Adoption of High-Performance Biomaterials with Cambium

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Biobased Alternatives to Synthetic Polymers with Bioweg

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A 3D rendering of a protein

Improving the Specificity and Activity of a Biocatalyst

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Sustainable Beauty and Personal Care Products with Sumitomo Chemical

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Developing Water Quality Biosensors with FREDSense

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Genes × Jeans: Accelerating Production of Sustainable Dyes with Huue

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Metabolic Engineering for Lower Cost Feedstocks

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Commercializing Cultured Ingredients with Robertet

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Ultra High Throughput Genome Engineering for the Production of Specialty Chemicals

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Nutrition & Wellness

Improve proteins and enzymes, fats and oils, flavors and fragrances, and so much more with synthetic biology. Explore our projects and learn more about how we help our partners in the nutrition and wellness sector.

Nutrition & Wellness

Celebrating Cronos Group’s First-of-a-Kind CBC Product

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Sustainable Beauty and Personal Care Products with Sumitomo Chemical

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Producing Rare, Natural Ingredients with Givaudan

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Scaled Production of Cultured CBG with Cronos Group

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Optimizing Enzyme Expression and Performance with Zymtronix

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Scaling Production of Cultured THCV with Cronos Group

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Optimizing Silk Protein Production with Bolt Threads

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Improving Production Efficiency for Vibrant Food Colors with Phytolon

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Metabolic Engineering for Lower Cost Feedstocks

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Launching Commercial Production of Cultured Cannabinoids with Cronos

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New Platform Ventures: Launching Verb Biotics, Ayana Bio

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Commercializing Cultured Ingredients with Robertet

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Frequently Asked Questions

Not seeing what you need? Contact us with your question, and we’ll get back to you.

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Is Ginkgo able to model the cost of goods sold (COGS) and techno-economic analyses (TEA) for my project?

Yes, typically as part of early program assessment, Ginkgo’s Deployment team uses platforms such as ASPEN, SuperPro, and spreadsheets to understand the marketability and cost of commercial programs.

What scales has Ginkgo helped customer projects achieve?

We have successfully guided customer projects from our labs to commercial production at the 50,000 L scale. Internally, Ginkgo can leverage bench scale devices (250 mL to 5 L) and pilot plant equipment (10 to 3,000 L) for upstream production and downstream purification. Additionally, Ginkgo has a large network of preferred manufacturing partners who have successfully scaled our customer’s strains to commercial scale.

What are Ginkgo’s end-to-end USP, DSP, process design, and scale up services?

From proof of concept projects to tech transfers to and from customers to scale up with manufacturing partners, Ginkgo supports customers in any phase of discovery, development, optimization, and commercialization.

Does Ginkgo offer analytical development services?

Yes, Ginkgo’s QA/QC team offers analytical development. Working with process development engineers, the QA/QC team provides the best paths toward process optimization that are in alignment with the customer’s target product profile.

What services specifically does Ginkgo offer in terms of quality assurance and control?

Ginkgo’s team provides project scope assessment, analytical technology transfer, analytical method development and validation, analytical titer/purity determination, and analytical quality support internally and externally to support scaled programs.