Ginkgo Natural Products Services

Overview

Engineer and optimize biosynthetic pathways for your natural products

Now, more than ever before, microbial biosynthesis is enabling mass production of molecules for a wide array of industries and applications. Leverage Ginkgo’s expertise in metabolic engineering and our foundry scale to program microorganisms to manufacture your molecule of interest.

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End-to-End Capabilities.
Unparalleled Scale.

Need to engineer a microbe for natural product biosynthesis from start to finish? Hit roadblocks or bottlenecks in your design? Need your industrial microbe’s flux improved? Ginkgo’s services can enable the optimization of your biosynthetic pathway, no matter the application.

Our expertise spans a range of industrial microbes—including Escherichia coli, Bacillus subtilis, Pichia pastoris, Saccharomyces cerevisiae, Aspergillus niger, Corynebacterium glutamicum, and Yarrowia lipolytica—and many more model and nonmodel host organisms.

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How can we help you?

Enzyme Discovery

Enzyme Discovery

Use our high throughput enzyme screening pipeline to discover the best enzyme for your enzymatic reaction: Ginkgo regularly screens 1,000+ enzymes in a single experiment, increasing our probability of finding the best enzyme that biology can offer
Leverage our computational biologist team and our proprietary software algorithms and AI tools to help select the most promising enzymes in the metagenomic space
Utilize Ginkgo’s proprietary gene database encompassing >1 billion genes and >8 million natural product gene clusters to give your project a unique competitive advantage

Pathway Tuning

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Pathway Tuning

Iteratively program complete biosynthetic pathways into one or more microorganisms after discovering the best enzymes for your product
Use Ginkgo’s high throughput DNA and strain construction capabilities to enable a thorough combinatorial balancing of your metabolic pathway
Leverage our Foundry to create and test thousands of strains during your project with high quality and high throughput mass spectrometry analysis of the target metabolites

Enzyme Optimization

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Enzyme Optimization

Engineer the enzymes in your biosynthesis pathway causing poor flux due to insufficient activity or expression
Leverage the scale of our Foundry to engineer thousands of enzymes in a single experiment using our high throughput testing pipelines
Access Ginkgo’s world-class protein engineering team and their proprietary software algorithms and AI tools to help you engineer the best enzymes possible in the fewest rounds of engineering

Fermentation Optimization

Fermentation Optimization

Rapidly evaluate strain candidates using our fleet of ~300 Sartorius Ambr® 250 bioreactors to automate design of experiments at lab scale to quickly develop fermentation processes with a proven record of transferring to commercial scale

Fermentation Scale Up, Process Design & Tech Transfer

Fermentation Scale Up, Process Design & Tech Transfer

Access our fermentation capacity, ranging from Ginkgo’s fleet of ~300 Sartorius Ambr® 250 bioreactors to our vessels spanning 1, 5, 10, 30, and 3,000 L and all the way up to the 50,000 L scale with our manufacturing partners, including GMP production
Optimize your downstream processing and purification methods
Utilize Ginkgo’s thermal, physical, and chemical separation capabilities to purify a sample for further analysis, testing, or proof of concept
Enjoy quick project starts thanks to Ginkgo’s incoming analytical technology transfer capabilities and ensure smooth tech transfers back to your team or to your manufacturing partner of choice
Receive cost modeling and feasibility assessments from our team to inform your decision-making

Classical Strain Improvement

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Classical Strain Improvement

Utilize Ginkgo’s automated adaptive laboratory evolution (ALE) instruments to improve genetically modified microbes by adapting your strains to harsh, industrially-relevant conditions with results in as little as a few months
Search through up to 1 million strain variants in a single run using our ultra high throughput screening platform built on nanoliter encapsulation technology, which provides nanoscale growth and assay compartments for diverse organisms including bacteria, yeast, filamentous species, and mammalian cells

EncapS for Bioproduction

Markets We Serve

Explore how biology is being used across industries and how Ginkgo can help you.

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Start a project today.

We program cells—enabling you to grow the future of medicine, materials, food, and more.

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Markets We Serve

Featured Projects & News

Ginkgo is your end-to-end synthetic biology R&D partner. Browse a selection of our partner projects and case studies to explore how biology is being used across industries.

Speak to our team today to access more.

Agriculture

Crop protection and nutrition, animal health and wellness, carbon solutions: we’re here to help. Explore our projects and learn more about how we help our partners in the agricultural sector.

Agriculture

WHAT WE DO