Ginkgo Enzyme Services

Overview

Discover, engineer, optimize, and scale up your enzyme

Whether you’re looking for a biocatalyst to replace a chemical synthesis step, looking to improve your enzyme’s function, or aiming to lower your manufacturing costs, Ginkgo’s best-in-class capabilities empower your enzyme R&D.

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End-to-End Capabilities.
Unparalleled Scale.

From computational design to novel enzyme discovery to commercial scale-up, Ginkgo’s services enable the discovery, optimization, and production of enzymes for diverse applications.

Leverage Ginkgo’s proprietary gene database encompassing >2 billion genes and >8 million natural product gene clusters as well as our advanced machine learning tools, ultra high throughput automation, and proprietary bacterial and fungal production hosts to search through the vastness of biological design space to discover novel enzyme activities, optimize enzyme function, improve expression, and scale up manufacturing processes for enzyme production.

How can we help you?

Discover New Enzymes

Discover New Enzymes

Discover novel enzyme activity and identify starting points for further protein engineering by drawing from our incredibly broad database of proprietary and public genomic sequences
Mine genome databases using our in-house computational tools to identify thousands of potential hits
Leverage metagenomic screens to design around existing IP that would otherwise block your development
Screen candidates using advanced ultra high throughput screening methods to identify unique enzymes with your desired activity

Optimize Enzyme Function & Stability

Optimize Enzyme Function & Stability

Use a broad and constantly expanding toolkit of evolutionary, computational, and rational protein engineering approaches to iteratively improve catalytic activity, enzyme stability, specificity, and expression
Dramatically improve your enzyme’s function by leveraging our platform’s supervised machine learning, powered by data from our ultra high throughput assays

Access Best-in-Class Production Hosts for Robust Expression

Access Best-in-Class Production Hosts for Robust Expression

Express your enzyme in our proprietary bacterial and fungal hosts optimized for protein production, including next-generation methanol-free Pichia pastoris and low viscosity Aspergillus niger
Leverage our deep strain engineering expertise to optimize enzyme expression in our high expression host strains, tailored to support optimal expression of your enzyme to reduce your production costs

Develop an Optimized Fermentation Process

Develop an Optimized Fermentation Process

Use our fleet of hundreds of Sartorius Ambr® 250 bioreactors to automate design of experiments at lab scale to quickly develop fermentation processes with a proven record of transferring to commercial scale

Fermentation Scale Up, Process Design & Tech Transfer

Fermentation Scale Up, Process Design & Tech Transfer

Access our fermentation capacity, ranging from Ginkgo’s fleet of ~300 Sartorius Ambr® 250 bioreactors to our vessels spanning 1, 5, 10, 30, and 3,000 L and all the way up to the 50,000 L scale with our manufacturing partners, including GMP production
Optimize your downstream processing and purification methods
Utilize Ginkgo’s thermal, physical, and chemical separation capabilities to purify a sample for further analysis, testing, or proof of concept
Enjoy quick project starts thanks to Ginkgo’s incoming analytical technology transfer capabilities and ensure smooth tech transfers back to your team or to your manufacturing partner of choice
Receive cost modeling and feasibility assessments from our team to inform your decision-making

Markets We Serve

Explore how biology is being used across industries and how Ginkgo can help you.

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Start a project today.

We program cells—enabling you to grow the future of medicine, food, materials, and more.

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Markets We Serve

Featured Projects & News

Ginkgo is your end-to-end synthetic biology R&D partner. Browse a selection of our partner projects and case studies to explore how biology is being used across industries.

Speak to our team today to access more.

Agriculture

Crop protection and nutrition, animal health and wellness, carbon solutions: we’re here to help. Explore our projects and learn more about how we help our partners in the agricultural sector.

Explore Agriculture

Agriculture

Biopharmaceutical

Use our synthetic biology platform to discover, optimize, and scale up a wide range of therapeutic modalities. Explore our projects and learn more about how we help our partners in the biopharmaceutical sector.

Biopharmaceutical

WHAT WE DO

Overview

Discover, engineer, optimize, and scale up your enzyme

End-to-End Capabilities. Unparalleled Scale.

Discover New Enzymes

Discover New Enzymes

Optimize Enzyme Function & Stability

Optimize Enzyme Function & Stability

Access Best-in-Class Production Hosts for Robust Expression

Access Best-in-Class Production Hosts for Robust Expression

Develop an Optimized Fermentation Process

Develop an Optimized Fermentation Process

Fermentation Scale Up, Process Design & Tech Transfer

Fermentation Scale Up, Process Design & Tech Transfer

Markets We Serve

Agriculture

Biopharmaceutical

Governments

Industrials

Nutrition & Wellness

…and many more!

Speak with Us

Start a project today.

Featured Projects & News

Agriculture

Biopharmaceutical

Optimizing Crucial Drug Manufacturing of APIs with Merck

Unlocking the Potential of Expression Systems for Medicines with Novo Nordisk

Improving the Specificity and Activity of a Biocatalyst

Enzyme Discovery Powered by Large Metagenomic Libraries

High Throughput Screening for Designing Novel CAR-T Cell Therapies

Manufacturing Breakthrough for mRNA Raw Materials with Aldevron

Advancing Treatments for Orphan and Rare Diseases with Selecta Biosciences

Developing Next-Generation Gene Therapy Capsids with Selecta Biosciences

Improving the Manufacture of Biosynthetic Heparin with Optimvia

Investigational Synthetic Biotic Medicine for Homocystinuria with Synlogic

Optimizing Enzyme Expression and Performance with Zymtronix

Developing Circular RNA-based Therapeutics with Esperovax

Engineering Bacteria for Cancer Patient Treatment with Prokarium

Improving Living Medicines with Synlogic

New Platform Ventures: Launching Verb Biotics, Ayana Bio

Accelerating Production of Essential Medicines with Antheia

Developing High-Efficacy Adjuvants for Vaccines with SaponiQx

Developing Synthetic Biotics for Gout with Synlogic

Discovering Novel Live Biotherapeutics with Microba

Engineering Living Biotherapeutics for Gastrointestinal Health with Tantu

Needle in a Haystack: Looking for Compounds to Treat COVID-19

Supporting COVID-19 mRNA Vaccine Development with Moderna

Teaming Up to Improve Antibody Therapeutics for COVID-19

A New Modality of Medicine: Nucleic Acid Vaccines

Discovering Enzymes for New Applications

Improving Titer with Process Optimization

The Era of Living Medicines with Synlogic

Governments

Detecting Engineered DNA with IARPA & Draper

Building a Global Immune System with Concentric by Ginkgo

Manufacturing Breakthrough for mRNA Raw Materials with Aldevron

Tracking Pathogen Variants with Rwanda Biomedical Centre

Supporting COVID-19 mRNA Vaccine Development with Moderna

Synthetic Biology for Climate Action

600,000 Noses Swabbed!

Expanding Ginkgo’s Platform for Biosecurity and Pandemic Responsiveness

Accelerating Industrial Adoption of High-Performance Biomaterials with Cambium

Developing Water Quality Biosensors with FREDSense

Concentric by Ginkgo: COVID-19 testing at scale

Our Work on Biosecurity with IARPA

Industrials

Optimizing Production of Biobased Speciality Chemicals with Lygos

Accelerating Industrial Adoption of High-Performance Biomaterials with Cambium

Biobased Alternatives to Synthetic Polymers with Bioweg

Improving the Specificity and Activity of a Biocatalyst

Sustainable Beauty and Personal Care Products with Sumitomo Chemical

Developing Water Quality Biosensors with FREDSense

Enhancing Biomaterials with Bolt Threads

Genes × Jeans: Accelerating Production of Sustainable Dyes with Huue

Synthetic Biology for Climate Action

Metabolic Engineering for Lower Cost Feedstocks

Commercializing Cultured Ingredients with Robertet

Discovering Enzymes for New Applications

End-to-End Capabilities.
Unparalleled Scale.

Ginkgo
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