Ginkgo Enzyme Services

Overview

Discover, engineer, optimize, and scale up your enzyme

Whether you’re looking for a biocatalyst to replace a chemical synthesis step, looking to improve your enzyme’s function, or aiming to lower your manufacturing costs, Ginkgo’s best-in-class capabilities empower your enzyme R&D.

Have a question or ready to start a project?

End-to-End Capabilities.
Unparalleled Scale.

From computational design to novel enzyme discovery to commercial scale-up, Ginkgo’s services enable the discovery, optimization, and production of enzymes for diverse applications.

Leverage Ginkgo’s proprietary gene database encompassing >2 billion genes and >8 million natural product gene clusters as well as our advanced machine learning tools, ultra high throughput automation, and proprietary bacterial and fungal production hosts to search through the vastness of biological design space to discover novel enzyme activities, optimize enzyme function, improve expression, and scale up manufacturing processes for enzyme production.

How can we help you?

Discover New Enzymes

Discover New Enzymes

  • Discover novel enzyme activity and identify starting points for further protein engineering by drawing from our incredibly broad database of proprietary and public genomic sequences

  • Mine genome databases using our in-house computational tools to identify thousands of potential hits

  • Leverage metagenomic screens to design around existing IP that would otherwise block your development

  • Screen candidates using advanced ultra high throughput screening methods to identify unique enzymes with your desired activity

Optimize Enzyme Function & Stability

Optimize Enzyme Function & Stability

  • Use a broad and constantly expanding toolkit of evolutionary, computational, and rational protein engineering approaches to iteratively improve catalytic activity, enzyme stability, specificity, and expression

  • Dramatically improve your enzyme’s function by leveraging our platform’s supervised machine learning, powered by data from our ultra high throughput assays

Access Best-in-Class Production Hosts for Robust Expression

Access Best-in-Class Production Hosts for Robust Expression

  • Express your enzyme in our proprietary bacterial and fungal hosts optimized for protein production, including next-generation methanol-free Pichia pastoris and low viscosity Aspergillus niger

  • Leverage our deep strain engineering expertise to optimize enzyme expression in our high expression host strains, tailored to support optimal expression of your enzyme to reduce your production costs

Develop an Optimized Fermentation Process

Develop an Optimized Fermentation Process

  • Use our fleet of hundreds of Sartorius Ambr® 250 bioreactors to automate design of experiments at lab scale to quickly develop fermentation processes with a proven record of transferring to commercial scale

Fermentation Scale Up, Process Design & Tech Transfer

Fermentation Scale Up, Process Design & Tech Transfer

  • Access our fermentation capacity, ranging from Ginkgo’s fleet of ~300 Sartorius Ambr® 250 bioreactors to our vessels spanning 1, 5, 10, 30, and 3,000 L and all the way up to the 50,000 L scale with our manufacturing partners, including GMP production

  • Optimize your downstream processing and purification methods

  • Utilize Ginkgo’s thermal, physical, and chemical separation capabilities to purify a sample for further analysis, testing, or proof of concept

  • Enjoy quick project starts thanks to Ginkgo’s incoming analytical technology transfer capabilities and ensure smooth tech transfers back to your team or to your manufacturing partner of choice

  • Receive cost modeling and feasibility assessments from our team to inform your decision-making

Speak with Us

Start a project today.

We program cells—enabling you to grow the future of medicine, food, materials, and more.

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Markets We Serve

Featured Projects & News

Ginkgo is your end-to-end synthetic biology R&D partner. Browse a selection of our partner projects and case studies to explore how biology is being used across industries.

Speak to our team today to access more.

Agriculture

Crop protection and nutrition, animal health and wellness, carbon solutions: we’re here to help. Explore our projects and learn more about how we help our partners in the agricultural sector.
Explore Agriculture

Agriculture

Biopharmaceutical

Use our synthetic biology platform to discover, optimize, and scale up a wide range of therapeutic modalities. Explore our projects and learn more about how we help our partners in the biopharmaceutical sector.

Biopharmaceutical

Optimizing Crucial Drug Manufacturing of APIs with Merck

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Unlocking the Potential of Expression Systems for Medicines with Novo Nordisk

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A 3D rendering of a protein

Improving the Specificity and Activity of a Biocatalyst

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Enzyme Discovery Powered by Large Metagenomic Libraries

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High Throughput Screening for Designing Novel CAR-T Cell Therapies

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Manufacturing Breakthrough for mRNA Raw Materials with Aldevron

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Advancing Treatments for Orphan and Rare Diseases with Selecta Biosciences

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Developing Next-Generation Gene Therapy Capsids with Selecta Biosciences

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Improving the Manufacture of Biosynthetic Heparin with Optimvia

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Investigational Synthetic Biotic Medicine for Homocystinuria with Synlogic

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Optimizing Enzyme Expression and Performance with Zymtronix

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Developing Circular RNA-based Therapeutics with Esperovax

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Engineering Bacteria for Cancer Patient Treatment with Prokarium

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New Platform Ventures: Launching Verb Biotics, Ayana Bio

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Accelerating Production of Essential Medicines with Antheia

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Developing High-Efficacy Adjuvants for Vaccines with SaponiQx

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Developing Synthetic Biotics for Gout with Synlogic

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Discovering Novel Live Biotherapeutics with Microba

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Engineering Living Biotherapeutics for Gastrointestinal Health with Tantu

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Needle in a Haystack: Looking for Compounds to Treat COVID-19

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Supporting COVID-19 mRNA Vaccine Development with Moderna

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Teaming Up to Improve Antibody Therapeutics for COVID-19

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A New Modality of Medicine: Nucleic Acid Vaccines

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Governments

Secure the things you care about the most — your people, your environment, your home. Explore our projects and learn more about how we help our partners in the public sector.

Governments

Building a Global Immune System with Concentric by Ginkgo

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Manufacturing Breakthrough for mRNA Raw Materials with Aldevron

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Tracking Pathogen Variants with Rwanda Biomedical Centre

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Supporting COVID-19 mRNA Vaccine Development with Moderna

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Expanding Ginkgo’s Platform for Biosecurity and Pandemic Responsiveness

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Accelerating Industrial Adoption of High-Performance Biomaterials with Cambium

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Developing Water Quality Biosensors with FREDSense

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Concentric by Ginkgo: COVID-19 testing at scale

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Industrials

Chemicals, materials, fuels, waste, mining, water treatment: biology is revolutionizing industrial processes. Explore our projects and learn more about how we help our partners in the industrial sectors.

Industrials

Aliquots

Optimizing Production of Biobased Speciality Chemicals with Lygos

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Accelerating Industrial Adoption of High-Performance Biomaterials with Cambium

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Biobased Alternatives to Synthetic Polymers with Bioweg

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A 3D rendering of a protein

Improving the Specificity and Activity of a Biocatalyst

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Sustainable Beauty and Personal Care Products with Sumitomo Chemical

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Developing Water Quality Biosensors with FREDSense

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Genes × Jeans: Accelerating Production of Sustainable Dyes with Huue

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Metabolic Engineering for Lower Cost Feedstocks

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Commercializing Cultured Ingredients with Robertet

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Ultra High Throughput Genome Engineering for the Production of Specialty Chemicals

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Nutrition & Wellness

Improve proteins and enzymes, fats and oils, flavors and fragrances, and so much more with synthetic biology. Explore our projects and learn more about how we help our partners in the nutrition and wellness sector.

Nutrition & Wellness

Celebrating Cronos Group’s First-of-a-Kind CBC Product

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Sustainable Beauty and Personal Care Products with Sumitomo Chemical

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Producing Rare, Natural Ingredients with Givaudan

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Scaled Production of Cultured CBG with Cronos Group

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Optimizing Enzyme Expression and Performance with Zymtronix

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Scaling Production of Cultured THCV with Cronos Group

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Optimizing Silk Protein Production with Bolt Threads

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Improving Production Efficiency for Vibrant Food Colors with Phytolon

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Metabolic Engineering for Lower Cost Feedstocks

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Launching Commercial Production of Cultured Cannabinoids with Cronos

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New Platform Ventures: Launching Verb Biotics, Ayana Bio

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Commercializing Cultured Ingredients with Robertet

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Cell Therapy Services

Learn about Ginkgo’s latest tech for cell therapy R&D, including recent data from our CAR screening platform.
We can help you discover novel CAR-T therapeutics, including candidates that are effective against solid tumors.

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