Ginkgo Natural Products Services

Overview

Engineer and optimize biosynthetic pathways for your natural products

Now, more than ever before, microbial biosynthesis is enabling mass production of molecules for a wide array of industries and applications. Leverage Ginkgo’s expertise in metabolic engineering and our foundry scale to program microorganisms to manufacture your molecule of interest.

Have a question or ready to start a project?

End-to-End Capabilities.
Unparalleled Scale.

Need to engineer a microbe for natural product biosynthesis from start to finish? Hit roadblocks or bottlenecks in your design? Need your industrial microbe’s flux improved? Ginkgo’s services can enable the optimization of your biosynthetic pathway, no matter the application.

Our expertise spans a range of industrial microbes—including Escherichia coli, Bacillus subtilis, Pichia pastoris, Saccharomyces cerevisiae, Aspergillus niger, Corynebacterium glutamicum, and Yarrowia lipolytica—and many more model and nonmodel host organisms.

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How can we help you?

Enzyme Discovery

Enzyme Discovery

  • Use our high throughput enzyme screening pipeline to discover the best enzyme for your enzymatic reaction: Ginkgo regularly screens 1,000+ enzymes in a single experiment, increasing our probability of finding the best enzyme that biology can offer

  • Leverage our computational biologist team and our proprietary software algorithms and AI tools to help select the most promising enzymes in the metagenomic space

  • Utilize Ginkgo’s proprietary gene database encompassing >1 billion genes and >8 million natural product gene clusters to give your project a unique competitive advantage

Pathway Tuning

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Pathway Tuning

  • Iteratively program complete biosynthetic pathways into one or more microorganisms after discovering the best enzymes for your product

  • Use Ginkgo’s high throughput DNA and strain construction capabilities to enable a thorough combinatorial balancing of your metabolic pathway

  • Leverage our Foundry to create and test thousands of strains during your project with high quality and high throughput mass spectrometry analysis of the target metabolites

Enzyme Optimization

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Enzyme Optimization

  • Engineer the enzymes in your biosynthesis pathway causing poor flux due to insufficient activity or expression

  • Leverage the scale of our Foundry to engineer thousands of enzymes in a single experiment using our high throughput testing pipelines

  • Access Ginkgo’s world-class protein engineering team and their proprietary software algorithms and AI tools to help you engineer the best enzymes possible in the fewest rounds of engineering

Fermentation Optimization

Fermentation Optimization

  • Rapidly evaluate strain candidates using our fleet of ~300 Sartorius Ambr® 250 bioreactors to automate design of experiments at lab scale to quickly develop fermentation processes with a proven record of transferring to commercial scale

Fermentation Scale Up, Process Design & Tech Transfer

Fermentation Scale Up, Process Design & Tech Transfer

  • Access our fermentation capacity, ranging from Ginkgo’s fleet of ~300 Sartorius Ambr® 250 bioreactors to our vessels spanning 1, 5, 10, 30, and 3,000 L and all the way up to the 50,000 L scale with our manufacturing partners, including GMP production

  • Optimize your downstream processing and purification methods

  • Utilize Ginkgo’s thermal, physical, and chemical separation capabilities to purify a sample for further analysis, testing, or proof of concept

  • Enjoy quick project starts thanks to Ginkgo’s incoming analytical technology transfer capabilities and ensure smooth tech transfers back to your team or to your manufacturing partner of choice

  • Receive cost modeling and feasibility assessments from our team to inform your decision-making

Classical Strain Improvement

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Classical Strain Improvement

  • Utilize Ginkgo’s automated adaptive laboratory evolution (ALE) instruments to improve genetically modified microbes by adapting your strains to harsh, industrially-relevant conditions with results in as little as a few months

  • Search through up to 1 million strain variants in a single run using our ultra high throughput screening platform built on nanoliter encapsulation technology, which provides nanoscale growth and assay compartments for diverse organisms including bacteria, yeast, filamentous species, and mammalian cells
EncapS for Bioproduction
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Speak with Us

Start a project today.

We program cells—enabling you to grow the future of medicine, materials, food, and more.

Contact Us
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Markets We Serve

Featured Projects & News

Ginkgo is your end-to-end synthetic biology R&D partner. Browse a selection of our partner projects and case studies to explore how biology is being used across industries.

Speak to our team today to access more.

Agriculture

Crop protection and nutrition, animal health and wellness, carbon solutions: we’re here to help. Explore our projects and learn more about how we help our partners in the agricultural sector.

Agriculture

Strain Improvement for Sustainable Agriculture with Bayer

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Ginkgo Expands Agricultural Biologicals Division, Closes Deal with Bayer

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Expanding Our Platform Capabilities in Agricultural Biologicals and Launching Flagship Partnership with Bayer

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Optimizing Enzyme Expression and Performance with Zymtronix

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Optimizing the Brightness of Glowing Plants with Light Bio

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Biopharmaceutical

Use our synthetic biology platform to discover, optimize, and scale up a wide range of therapeutic modalities. Explore our projects and learn more about how we help our partners in the biopharmaceutical sector.

Biopharmaceutical

Optimizing Crucial Drug Manufacturing of APIs with Merck

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Unlocking the Potential of Expression Systems for Medicines with Novo Nordisk

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Improving the Specificity and Activity of a Biocatalyst

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Enzyme Discovery Powered by Large Metagenomic Libraries

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High Throughput Screening for Designing Novel CAR-T Cell Therapies

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Manufacturing Breakthrough for mRNA Raw Materials with Aldevron

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Advancing Treatments for Orphan and Rare Diseases with Selecta Biosciences

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Developing Next-Generation Gene Therapy Capsids with Selecta Biosciences

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Improving the Manufacture of Biosynthetic Heparin with Optimvia

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Investigational Synthetic Biotic Medicine for Homocystinuria with Synlogic

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Optimizing Enzyme Expression and Performance with Zymtronix

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Developing Circular RNA-based Therapeutics with Esperovax

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Engineering Bacteria for Cancer Patient Treatment with Prokarium

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New Platform Ventures: Launching Verb Biotics, Ayana Bio

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Accelerating Production of Essential Medicines with Antheia

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Developing High-Efficacy Adjuvants for Vaccines with SaponiQx

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Developing Synthetic Biotics for Gout with Synlogic

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Discovering Novel Live Biotherapeutics with Microba

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Engineering Living Biotherapeutics for Gastrointestinal Health with Tantu

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Needle in a Haystack: Looking for Compounds to Treat COVID-19

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Supporting COVID-19 mRNA Vaccine Development with Moderna

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Teaming Up to Improve Antibody Therapeutics for COVID-19

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A New Modality of Medicine: Nucleic Acid Vaccines

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Governments

Secure the things you care about the most — your people, your environment, your home. Explore our projects and learn more about how we help our partners in the public sector.

Governments

Building a Global Bioradar System with Concentric by Ginkgo

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Manufacturing Breakthrough for mRNA Raw Materials with Aldevron

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Tracking Pathogen Variants with Rwanda Biomedical Centre

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Supporting COVID-19 mRNA Vaccine Development with Moderna

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Expanding Ginkgo’s Platform for Biosecurity and Pandemic Responsiveness

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Accelerating Industrial Adoption of High-Performance Biomaterials with Cambium

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Developing Water Quality Biosensors with FREDSense

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Concentric by Ginkgo: COVID-19 testing at scale

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Industrials

Chemicals, materials, fuels, waste, mining, water treatment: biology is revolutionizing industrial processes. Explore our projects and learn more about how we help our partners in the industrial sectors.

Industrials

Aliquots

Optimizing Production of Biobased Speciality Chemicals with Lygos

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Accelerating Industrial Adoption of High-Performance Biomaterials with Cambium

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Biobased Alternatives to Synthetic Polymers with Bioweg

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Improving the Specificity and Activity of a Biocatalyst

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Sustainable Beauty and Personal Care Products with Sumitomo Chemical

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Developing Water Quality Biosensors with FREDSense

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Genes × Jeans: Accelerating Production of Sustainable Dyes with Huue

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Metabolic Engineering for Lower Cost Feedstocks

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Commercializing Cultured Ingredients with Robertet

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Ultra High Throughput Genome Engineering for the Production of Specialty Chemicals

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Nutrition & Wellness

Improve proteins and enzymes, fats and oils, flavors and fragrances, and so much more with synthetic biology. Explore our projects and learn more about how we help our partners in the nutrition and wellness sector.

Nutrition & Wellness

Celebrating Cronos Group’s First-of-a-Kind CBC Product

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Sustainable Beauty and Personal Care Products with Sumitomo Chemical

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Producing Rare, Natural Ingredients with Givaudan

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Scaled Production of Cultured CBG with Cronos Group

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Optimizing Enzyme Expression and Performance with Zymtronix

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Scaling Production of Cultured THCV with Cronos Group

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Optimizing Silk Protein Production with Bolt Threads

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Improving Production Efficiency for Vibrant Food Colors with Phytolon

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Metabolic Engineering for Lower Cost Feedstocks

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Launching Commercial Production of Cultured Cannabinoids with Cronos

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New Platform Ventures: Launching Verb Biotics, Ayana Bio

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Commercializing Cultured Ingredients with Robertet

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