Therapeutics and Vaccines

Overview

Unleash the full potential of your R&D team

Ginkgo’s services empower customers across all stages of the drug development pipeline, from discovery through manufacturing. Our world-class synthetic biology platform combines computational design and ultra high throughput genetic engineering and screening with expertise in process development and manufacturing scale-up. Ginkgo helps your R&D team develop more effective therapeutics and solve your greatest drug development challenges.

Get in touch with the Ginkgo team today to discuss your R&D challenges!
[email protected]

Harness biology’s full breadth
for therapeutics and vaccines.

From small molecule discovery and manufacturing to biologics, cell & gene therapy, RNA therapeutics and vaccines, and beyond, Ginkgo is your cell engineering partner. Our services enable discovery, optimization, and scale up for a wide range of therapeutics modalities. See below for a selection of our application areas and case studies.

Select Application Areas

Biocatalysis & Biosynthesis for API Manufacturing

Biocatalysis & Biosynthesis for API Manufacturing

• Discover and optimize the activity, function, and manufacturing of enzymes to replace chemical synthesis steps

• Leverage our metabolic engineering expertise to create sustainable production processes and supply chains for small molecule medicines via fermentation

• Engineer production host organisms to optimize manufacturing processes

RNA Therapeutics & Vaccines

RNA Therapeutics & Vaccines

• Utilize proprietary assays and ultra high throughput screening to optimize the activity and stability of linear and circular RNA for enhanced function and tissue-specific expression and manufacture candidates in quantities ready for animal studies

• Optimize the activity and production of enzyme reagents used in RNA manufacturing and in vitro translation

• Increase plasmid titer and optimize downstream processing yield to reduce manufacturing costs

Cell Therapies

Cell Therapies

• Design and screen large pooled combinatorial libraries of CAR domains to find the most effective design for improved persistence

• Develop and optimize synthetic inducible promoters for expression and targeting of CAR therapies

• Optimize construction of CAR-T, CAR-NK, and other cell types with iPSC genomic safe harbors

Gene Therapies

Gene Therapies

• Engineer viral capsids to develop gene therapies with enhanced tropism, reduced immunogenicity, and improved transduction efficiency

• Engineer payloads with custom regulatory elements and inverted terminal repeats (ITRs) to improve efficiency and efficacy

• Design and optimize more productive cell lines and processes for efficient gene therapy production

Biologics Discovery & Manufacturing

Biologics Discovery & Manufacturing

• Design novel therapeutic proteins with high throughput assays for function and manufacturability

• Optimize protein expression in microbial host cells for reduced manufacturing costs

Microbiome

Microbiome

• Use high throughput characterization to identify key gut microbiome strains and their modes of action

• Develop living medicines through metabolic engineering and enzyme optimization

• Create more effective microbiome therapies using ultra high throughput screening to evaluate impact of microbiome produced small molecules on immune system

And more…

And more…

• Discover natural products and gene editing systems using genome mining of proprietary sequence databases

• Develop new modalities

Speak with Us

Start a project today.

We program cells—enabling you to grow the future of medicine, materials, food, and more.

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Featured Projects

Tune In

Join us at our next virtual event.

Chat with the Ginkgo team during our Jan. 18 virtual event to learn how Ginkgo uses massive experimental datasets and machine learning to enable enzyme engineering for customers.

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